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Metrics details. Stress-related psychiatric disorders, such as unipolar depression and post-traumatic stress disorder PTSD , occur more frequently in women than in men. Emerging research suggests that sex differences in receptors for the stress hormones, corticotropin releasing factor CRF and glucocorticoids, contribute to this disparity. For example, sex differences in CRF receptor binding in the amygdala of rats may predispose females to greater anxiety following stressful events. Additionally, sex differences in CRF receptor signaling and trafficking in the locus coeruleus arousal center combine to make females more sensitive to low levels of CRF, and less adaptable to high levels. These receptor differences in females could lead to hyperarousal, a dysregulated state associated with symptoms of depression and PTSD.
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Sex differences in micro- and macro-vascular complications of diabetes mellitus

Vascular complications are a leading cause of morbidity and mortality in both men and women with type 1 T1DM or type 2 T2DM diabetes mellitus, however the prevalence, progression and pathophysiology of both microvascular nephropathy, neuropathy and retinopathy and macrovascular [coronary heart disease CHD , myocardial infarction, peripheral arterial disease PAD and stroke] disease are different in the two sexes. In general, men appear to be at a higher risk for diabetic microvascular complications, while the consequences of macrovascular complications may be greater in women. Interestingly, in the absence of diabetes, women have a far lower risk of either micro- or macro-vascular disease compared with men for much of their lifespan. Thus, the presence of diabetes confers greater risk for vascular complications in women compared with men and some of the potential reasons, including contribution of sex hormones and sex-specific risk factors are discussed in this review.
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Sex differences in micro- and macro-vascular complications of diabetes mellitus

Vascular complications are a leading cause of morbidity and mortality in both men and women with type 1 T1DM or type 2 T2DM diabetes mellitus, however the prevalence, progression and pathophysiology of both microvascular nephropathy, neuropathy and retinopathy and macrovascular [coronary heart disease CHD , myocardial infarction, peripheral arterial disease PAD and stroke] disease are different in the two sexes. In general, men appear to be at a higher risk for diabetic microvascular complications, while the consequences of macrovascular complications may be greater in women. Interestingly, in the absence of diabetes, women have a far lower risk of either micro- or macro-vascular disease compared with men for much of their lifespan. Thus, the presence of diabetes confers greater risk for vascular complications in women compared with men and some of the potential reasons, including contribution of sex hormones and sex-specific risk factors are discussed in this review.
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Christine Maric-Bilkan; Sex differences in micro- and macro-vascular complications of diabetes mellitus. Clin Sci Lond 1 May ; 9 : — In general, men appear to be at a higher risk for diabetic microvascular complications, while the consequences of macrovascular complications may be greater in women. Interestingly, in the absence of diabetes, women have a far lower risk of either micro- or macro-vascular disease compared with men for much of their lifespan. Thus, the presence of diabetes confers greater risk for vascular complications in women compared with men and some of the potential reasons, including contribution of sex hormones and sex-specific risk factors are discussed in this review.
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